Madonna and Child

The paintings are in tempera with gold ground on wood panel. It originally had at least five compartments organised in two registers, making ten main panels, of which only four are known to have survived. Another four side panels and three predella panels (two of which had a double scene) are now in the Gemäldegalerie, Berlin. The altarpiece's central panel was Madonna and Child with Angels, produced in collaboration with Masaccio's brother Giovanni and with Andrea di Giusto, now in the National Gallery, London.

Eleven panels are known as of 2010, and they are insufficient to reconstruct the whole work with certainty. In particular four standing figures of saints flanking the central panel are missing. Vasari says these were the saints shown in the predella narrative scenes: Peter, John the Baptist, Julian and Nicholas. In particular it is unclear if these larger saints occupied the more traditional individual framed compartments, as proposed by C. Gardner von Teuffel and others, or stood in a unified field with the central Virgin and Child, as proposed by John Shearman, which was to become the usual style in the following decades.